1. Kidney and its collecting system

• Renal inflammation
• clinical manifestations of renal diseases;
• pathogenesis of glomerular diseases;
• glomerulonephritis caused by circulating immune complexes;
• glomerulonephritis caused by in situ immune complexes;
• anti-glomerular basement membrane antibody-mediated glomerulonephritis;
• nephritic syndrome;
• minimal-change disease;
• focal segmental glomerulosclerosis;
• membranous nephropathy;
• membranoproliferative glomerulonephritis and dense deposit disease;
• acute postinfectious glomerulonephritis;
• IgA nephropathy;
• rapidly progressive glomerulonephritis;
• hereditary nephritis;
• crescentic glomerulonephritis;
• diseases affecting tubules and interstitium;
• tubulointerstitial nephritis;
• acute pyelonephritis;
• chronic nephritis and 
• relux nephropathy;
• drug-induced interstitial nephritis;
• acute tubular injury;
• diseases involving renal blood vessels;
• arterionephroslcerosis;
• malignant hypertension;
• thrombotic microangiopathies;
• chronic kidney disease.
• Cystic diseases of the kidney:
• simple cysts;
• autosomal dominant (adult) polycystic kidney disease;
• autosomal recessive (childhood) polycystic kidney disease;
• medullary diseases with cysts.
• Urinary outflow obstruction:
• renal stones;
• hydronephrosis.
• Tumors of the kidney and urinary tract:
• renal cell carcinoma;
• Wilms tumor;
• tumors of the bladder and urinary tract.

2. Male reproductive system:

• congenital penile anomalies;
• inflammatory penile disorders;
• neoplasms of penis;
• cryptorchidism and testicular atrophy;
• inflammatory lesions;
• testicular neoplasms;
• prostatitis;
• benign prostatic hyperplasia (nodular hyperplasia);
• carcinoma of the prostate;
• sexually transmitted diseases;
• syphilis;
• gonorrhea;
• gonococcal urethritis;
• lymphogranuloma venereum;
• chancroid (soft chancre);
• granuloma inguinale;
• trichomoniasis;
• genital herpes simplex;
• human papillomavirus infection.

3. Breast pathology:

• definition of terminal ducto-lobular unit (TDLU);
• breast inflammation:
• acute inflammation;
• periductal inflammation;
• plasma cell inflammation;
• granulomatous inflammation of breast acini;
• tuberculosis;
• sarcoidosis;
• silicosis;
• lesions of breast predisposing to breast cancer;
• fibrocystic changes;
• radial scar;
• sclerosing adenosis;
• epithelial hyperplasia with/without atypia;
• tumors of the breast:
• invasive and non-invasive carcinoma;
• Paget’s disease;
• intraductal papilloma;
• inflammatory carcinoma;
• angiosarcoma;
• fibroadenoma;
• phyllodes tumor;
• the role of core biopsy in diagnosis of breast diseases;
• lesions of the male breast;
• gynecomastia;
• carcinoma.

4. Female reproductive system

• non-neoplastic disease of the ovary: types of cysts;
• polycystic ovarian syndrome;
• tumors of the ovary;
• surface epithelial tumors:
• serous tumors (benign, borderline, malignant);
• mucinous tumors (benign, borderline, malignant);
• endometrioid tumors (benign, borderline, malignant);
• clear cell tumors (benign, borderline, malignant);
• Brenner tumor;
• sex-cord stromal tumors:
• granulosa cell tumor;
• thecoma;
• fibroma;
• fibrothecoma;
• Sertoli and Leydig cell tumors;
• gynandroblastoma;
• lipid cell tumor;
• germ cell tumors:
• dysgerminoma;
• teratoma;
• embryonal carcinoma;
• yolk sac tumor;
• choriocarcinoma;
• mixed germ cell tumors;
• mixed tumors;
• metastases to ovary.
• Cervix
• cervicitis;
• ectopy and erosion of the cervix;
• endocervical polyp;
• CIN - cervical intraepithelial neoplasia;
• the role of HPV infection;
• Bethesda system;
• cervical carcinoma: types, etiology, epidemiology, risk factors, prevention. 
• Uterus:
• abnormal uterine bleeding;
• endometrial hyperplasia: non-atypical and atypical ;
• carcinoma of the uterus: types, etiology, epidemiology, risk factors, prevention;
• mesenchymal neoplasms: leiomyomas, leiomyosarcoma, stromal tumors;
• endometriosis.
• Gestational trophoblastic disease:
• hydatidiform mole;
• invasive mole;
• gestational choriocarcinoma.

5. Soft tissue pathology:

• definition and classification of soft tissue tumors;
• the role of pathologist in the diagnosis of soft tissue tumors;

• lipoma:
• localization, macro- and microscopic features;
• histological types:
• fibrolipoma;
• angiolipoma;
• myolipoma;
• myelolipoma;
• angiomyolipoma;
• liposarcoma:
• localization, macro- and microscopic features;
• histological types:
• pleomorphic;
• well-differentiated;
• myxoid;
• dedifferentiated;
• leiomyoma;
• leiomyosarcoma;
• vascular tumors:
• hemangioma;
• cavernous hemangioma;
• capillary hemangioma;
• lobular capillary hemangioma (granuloma pyogenicum);
• lymphangioma;
• cavernous lymphangioma;
• glomus tumor;
• osler-Weber-Rendu disease;
• angiomatosis bacillaris;
• Kaposi sarcoma.
• rhabdomyoma;
• rhabdomyosarcoma.

6. Bone and cartilage pathology:

• the role of imaging in the diagnostic process of bone and cartilage tumors;
• the importance of clinical and imaging correlation with pathologic report in the diagnostic process of bone tumors;
• bone neoplasm: 
• osteoma;
• osteoid osteoma;
• osteoblastoma;
• osteosarcoma;
• cartilage neoplasm:
• exostosis osteochondromatosis;
• chondroma;
• chondrosarcoma;
• other neoplasm:
• Ewing sarcoma;
• giant cell tumor;
• aneurysmal bone cyst (ABC).

7. CNS pathology:

• vascular diseases of the CNS;
• total CNS ischemia;
• intracranial  hemorrhage;
• congenital vascular malformations;
• infections of the CNS;
• epidural and subdural infections;
• meningitis;
• acute pyogenic meningitis;
• viral meningitis;
• chronic meningitis;
• tuberculous meningitis;
• brain abscess;
• intraparenchymal infections;
• demyelinating diseases;
• multiple sclerosis;
• neurodegenerative diseases;
• Alzheimer disease;
• Pick’s disease;
• Parkinson disease;
• Huntington disease.
• an increasing role of molecular pathology in diagnosis of CNS tumors;
• CNS tumors: epidemiology, signs and symptoms depending on the location, biological potential of the tumors;
• gliomas;

• ependymomas;
• embryonic tumors: medulloblastoma;
• meningiomas;
• tumors of the peripheral nervous system;
• metastases;

• paraneoplastic syndrome.

8. Skin pathology:

• types of skin biopsy;
• acute inflammatory dermatoses;
• urticaria;
• acute eczematous dermatitis;
• erythema multiforme;
• chronic inflammatory dermatoses;
• psoriasis;
• lichen planus;
• blistering (bullous) disorders;
• pemphigus;
• bullous pemphigoid;
• dermatitis herpetiformis;
• seborrheic keratosis;
• the role of pathologist in the diagnostic process of non-neoplastic diseases of the skin;
• precancerous lesions and diseases;
• actinic keratosis;
• Xeroderma pigmentosum;
• skin neoplasm:
• epithelial tumors: basal cell carcinoma and squamous cell carcinoma;
• melanocytic tumors;
• nevi;
• melanoma: types, classification, risk factors, prognostic factors, Clark and Breslow scale. 

9. Hematopoietic and lymphoid systems:

Anatomy, histology and physiology of hematopoietic and lymphoid systems is required.

• neoplastic proliferations of white cells

Clinical course, WHO classification, microscopical image, prognosis 

• chronic myeloproliferative disease;
• myelodysplastic disorders;
• myelodysplastic/myeloproliferative neoplasms;
• acute leukemias;
• mastocytosis;

Definition of blast cell and clone cell in neoplastic proliferations. Methods of identification of blast cells using immunohistochemistry.

Antibodies used to detect granulocytic series, erythroblastic series, megakaryocyte series and mast cells.

Diagnostic methods of proliferative diseases of bone marrow. 

Indications for bone marrow biopsy, methods of bone marrow biopsy, fixation and basic histochemical stains

• Non-neoplastic proliferations of white cells - definitions, types:

1. anemias;
2. polycythemia;
3. leukopenia;
4. leukocytosis;
5. thrombocytopenia;
6. coagulation disorders;
7. eosinophilic disorders;

•  Diseases of lymphoid system

Anatomy and histology of lymphoid system.

• Reactive lymph nodes

 Basic diseases:

• mononucleosis;
• lymphadenopathy in AIDS;
• progressive transformation of germinal centers (PTGC);
• castleman disease;
• toxoplasmosis;
• viral infections;
• silicon lymphadenopathy;
• lymphadenopathy in Wipple’s disease;
• cat scratch disease;
• lymphadenopathy in lupus erythematosus;
• dermatopathic lymphadenopathy;
• granulomatous lymphadenitis.

 Lymphoid tissue neoplastic diseases:

• WHO classification;
• lymphoid cell phenotype-definition; 
• antibodies used in diagnosis of lymphomas;
• phenotype of B-cell, T-cell and plasma cell;
• types and phenotype of dendritic and histiocytic cells;
• nodal and extranodal lymphomas.

Basic lymphomas, clinical course, epidemiology, phenotype:

• Hodgkin lymphoma;
• lymphoblastic leukemia/lymphoma;
• non-Hodgkin lymphomas;
• small cell B-cell lymphomas: lymphocytic lymphoma/chronic lymphocytic leukemia;
• mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma;
• large B-cell lymphoma, Burkitt lymphoma, plasma cell proliferative diseases;
• T-cell lymphomas:  anaplastic Alk+ i Alk-, skin lymphomas, peripheral T-cell lymphomas;
• dendritic and histiocytic proliferative diseases.

Neoplastic and non-neoplastic diseases of thymus and spleen.

10. Cytology
11. Immunohistochemistry and molecular diagnosis