1. Cardiovascular system, part II:

• heart failure: left and right sided heart failure;
• congenital heart disease;
• ischemic heart disease;
• endocarditis - non-infective and infective;
• degenerative and rheumatic valvular diseases;
• myocarditis;
• pericardial disease;
• cardiac tumors.

2. Upper gastrointestinal tract - diseases of the oral cavity, esophagus and stomach:

• Oral cavity: 
• oral inflammatory lesions;
• leukoplakia and erythroplakia;
• proliferative and neoplastic diseases.
• Salivary glands: 
• non-neoplastic: sialolithiasis, acute and chronic sialadenitis, mucocele; Sjogren syndrome;
• neoplastic (benign and malignant): pleomorphic adenoma, basal cell adenoma, Warthin tumor, acinic cell carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma;
• the role of FNA in salivary gland tumors classification.
• Esophagus: 
• esophagitis;
• precancerous lesions of squamous cell- and adenocarcinoma;
• Barrett esophagus;
• esophageal carcinomas: squamous cell- and adenocarcinoma: epidemiology, etiology, risk factors, signs and symptoms, histology, prognostic factors
• other tumors of the esophagus;
• the role of biopsy in the diagnosis of esophageal diseases
• Stomach:
• gastritis: acute vs. chronic;
• gastric ulcer: acute vs. chronic;
• helicobacter pylori infection: epidemiology, etiology, signs and symptoms, complications;
• gastric polyps;
• precancerous lesions of gastric carcinoma;
• gastric carcinoma: types, epidemiology, etiology, risk factors, signs and symptoms, prognostic factors;
• classifications in gastric carcinoma: Bormann classification; WHO classification; Lauren classification; TNM classification;
• early gastric carcinoma: definition and prognosis;
• other tumors of stomach: gastrointestinal stromal tumor (GIST), other mesenchymal tumors, lymphomas, neuroendocrine tumors.

3. Gut:

• the role of pathologist in the diagnostic process of bowel diseases and the importance of clinical correlation;
• inflammatory bowel disease: Crohn’s disease, ulcerative colitis;
• Crohn’s disease - etiology, epidemiology, gross and microscopic features, complications;
• ulcerative colitis - etiology, epidemiology, gross and microscopic features, complications;
• Crohn's disease vs. ulcerative colitis - differences and common features. The role of pathologist in the diagnostic process of both entities. Limitations of biopsy.;
• inflammatory bowel disease vs. infectious diseases of the intestine - the role of pathologist and the importance of clinical correlation;
• polyps - definition, types of polyps; 
• gastrointestinal polyposis syndromes;
• adenocarcinoma of the large bowel: epidemiology, etiology, risk factors, signs and symptoms, prognostic factors, TNM classification;
• neoplasms of the appendix;
• neuroendocrine tumors of the GI tract: types, classification, key differences between neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC). 

4. Pathology of liver, pancreas and biliary tract. 

• Pancreas:
• non-neoplastic diseases: true cysts and pseudocysts, acute and chronic pancreatitis, fatty necrosis;
• neoplastic diseases: PanIn (pancreatic intraepithelial neoplasia), ductal adenocarcinoma, acinic carcinoma, neuroendocrine tumors, IPMN (intraepithelial mucinous neoplasm), MCN (mucinous cystic neoplasm).

• Liver:

• non-neoplastic diseases: cirrhosis, acute and chronic hepatitis, passive hyperemia of the liver, vascular pathology, hepatic hypertension, liver steatosis; focal nodular hyperplasia (FNH);
• Neoplastic disease: types of hepatic adenoma; hepatocellular carcinoma and cholangiocarcinoma; other common neoplasm of the liver e.g. cavernous hemangioma.
• Core biopsy of the liver - indications and contradictions.

• Biliary tract:
• gallbladder pathology: cholelithiasis, inflammation and neoplasms;
• billiary tract pathology: choledocholithiasis, primary biliary cholangitis, neoplastic diseases.

5. Kidney and its collecting system:

• Renal inflammation
• clinical manifestations of renal diseases;
• pathogenesis of glomerular diseases;
• glomerulonephritis caused by circulating immune complexes;
• glomerulonephritis caused by in situ immune complexes;
• anti-glomerular basement membrane antibody-mediated glomerulonephritis;
• nephritic syndrome;
• minimal-change disease;
• focal segmental glomerulosclerosis;
• membranous nephropathy;
• membranoproliferative glomerulonephritis and dense deposit disease;
• acute postinfectious glomerulonephritis;
• IgA nephropathy;
• rapidly progressive glomerulonephritis;
• hereditary nephritis;
• crescentic glomerulonephritis;
• diseases affecting tubules and interstitium;
• tubulointerstitial nephritis;
• acute pyelonephritis;
• chronic nephritis and reflux nephropathy;
• drug-induced interstitial nephritis;
• acute tubular injury;
• diseases involving renal blood vessels;
• arterionephrosclerosis;
• malignant hypertension;
• thrombotic microangiopathies;
• chronic kidney disease.
• Cystic diseases of the kidney:
• simple cysts;
• autosomal dominant (adult) polycystic kidney disease;
• autosomal recessive (childhood) polycystic kidney disease;
• medullary diseases with cysts.
• Urinary outflow obstruction:
• renal stones;
• hydronephrosis.
• Tumors of the kidney and urinary tract:
• renal cell carcinoma;
• Wilms tumor;
• tumors of the bladder and urinary tract.

6. Male reproductive system

• congenital penile anomalies;
• inflammatory penile disorders;
• neoplasms of penis;
• cryptorchidism and testicular atrophy;
• inflammatory lesions;
• testicular neoplasms;
• prostatitis;
• benign prostatic hyperplasia (nodular hyperplasia);
• carcinoma of the prostate;
• sexually transmitted diseases;
• syphilis;
• gonorrhea;
• gongonococcal urethritis;
• lymphogranuloma venereum;
• chancroid (soft chancre);
• granuloma inguinale;
• trichomoniasis;
• genital herpes simplex;
• human papillomavirus infection.

7. Female reproductive system:

• non-neoplastic disease of the ovary: types of cysts;
• polycystic ovarian syndrome;
• tumors of the ovary;
• surface epithelial tumors:
• serous tumors (benign, borderline, malignant);
• mucinous tumors (benign, borderline, malignant);
• endometrioid tumors (benign, borderline, malignant);
• clear cell tumors (benign, borderline, malignant);
• Brenner tumor;
• sex-cord stromal tumors:
• granulosa cell tumor;
• thecoma;
• fibroma;
• fibrothecoma;
• Sertoli and Leydig cell tumors;
• gynandroblastoma;
• lipid cell tumor;
• germ cell tumors:
• dysgerminoma;
• teratoma;
• embryonal carcinoma;
• yolk sac tumor;
• choriocarcinoma;
• mixed germ cell tumors;
• mixed tumors;
• metastases to ovary.
• Cervix
• cervicitis;
• ectopy and erosion of the cervix;
• endocervical polyp;
• CIN - cervical intraepithelial neoplasia;
• the role of HPV infection;
• Bethesda system;
• cervical carcinoma: types, etiology, epidemiology, risk factors, prevention. 
• Uterus:
• abnormal uterine bleeding;
• endometrial hyperplasia: non-atypical and atypical ;
• carcinoma of the uterus: types, etiology, epidemiology, risk factors, prevention;
• mesenchymal neoplasms: leiomyomas, leiomyosarcoma, stromal tumors;
• endometriosis.
• Gestational trophoblastic disease:
• hydatidiform mole;
• invasive mole;
• gestational choriocarcinoma.

8. Breast pathology:

• definition of terminal ducto-lobular unit (TDLU);
• breast inflammation:
• acute inflammation;
• periductal inflammation;
• plasma cell inflammation;
• granulomatous inflammation of breast acini;
• tuberculosis;
• sarcoidosis;
• silicosis;
• lesions of breast predisposing to breast cancer;
• fibrocystic changes;
• radial scar;
• sclerosing adenosis;
• epithelial hyperplasia with/without atypia;
• tumors of the breast:
• invasive and non-invasive carcinoma;
• Paget’s disease;
• intraductal papilloma;
• inflammatory carcinoma;
• angiosarcoma;
• fibroadenoma;
• phyllodes tumor;
• the role of core biopsy in diagnosis of breast diseases;
• lesions of the male breast;
• gynecomastia;
• carcinoma.

9. Skin pathology:

• types of skin biopsy;
• acute inflammatory dermatoses;
• urticaria;
• acute eczematous dermatitis;
• erythema multiforme;
• chronic inflammatory dermatoses;
• psoriasis;
• lichen planus;
• blistering (bullous) disorders;
• pemphigus;
• bullous pemphigoid;
• dermatitis herpetiformis;
• seborrheic keratosis;
• the role of pathologist in the diagnostic process of non-neoplastic diseases of the skin;
• precancerous lesions and diseases;
• actinic keratosis;
• Xeroderma pigmentosum;
• skin neoplasm:
• epithelial tumors: basal cell carcinoma and squamous cell carcinoma;
• melanocytic tumors;
• nevi;
• melanoma: types, classification, risk factors, prognostic factors, Clark and Breslow scale. 

10. Bone and cartilage pathology:

• the role of imaging in the diagnostic process of bone and cartilage tumors;
• the importance of clinical and imaging correlation with pathologic report in the diagnostic process of bone tumors;
• bone neoplasm: 
• osteoma;
• osteoid osteoma;
• osteoblastoma;
• osteosarcoma;
• cartilage neoplasm:
• exostosis osteochondromatosis;
• chondroma;
• chondrosarcoma;
• other neoplasm:
• Ewing sarcoma;
• giant cell tumor;
• aneurysmal bone cyst (ABC).

11. Pathology of the central nervous system (CNS)

• vascular diseases of the CNS;
• total CNS ischemia;
• intracranial  hemorrhage;
• congenital vascular malformations;
• infections of the CNS;
• epidural and subdural infections;
• meningitis;
• acute pyogenic meningitis;
• viral meningitis;
• chronic meningitis;
• tuberculous meningitis;
• brain abscess;
• intraparenchymal infections;
• demyelinating diseases;
• multiple sclerosis;
• neurodegenerative diseases;
• Alzheimer disease;
• Pick’s disease;
• Parkinson disease;
• Huntington disease.

12. CNS tumors:

• an increasing role of molecular pathology in diagnosis of CNS tumors;
• CNS tumors: epidemiology, signs and symptoms depending on the location, biological potential of the tumors;
• gliomas;

• ependymomas;
• embryonic tumors: medulloblastoma;
• meningiomas;
• tumors of the peripheral nervous system;
• metastases;

• paraneoplastic syndrome.

13. Hematopoietic and lymphoid systems:

Anatomy, histology and physiology of hematopoietic and lymphoid systems is required.

• neoplastic proliferations of white cells

Clinical course, WHO classification, microscopical image, prognosis 

• chronic myeloproliferative disease;
• myelodysplastic disorders;
• myelodysplastic/myeloproliferative neoplasms;
• acute leukemias;
• mastocytosis;

Definition of blast cell and clone cell in neoplastic proliferations. Methods of identification of blast cells using immunohistochemistry.

Antibodies used to detect granulocytic series, erythroblastic series, megakaryocyte series and mast cells.

Diagnostic methods of proliferative diseases of bone marrow. 

Indications for bone marrow biopsy, methods of bone marrow biopsy, fixation and basic histochemical stains

• Non-neoplastic proliferations of white cells - definitions, types:

1. anemias;
2. polycythemia;
3. leukopenia;
4. leukocytosis;
5. thrombocytopenia;
6. coagulation disorders;
7. eosinophilic disorders;

•  Diseases of lymphoid system

Anatomy and histology of lymphoid system.

• Reactive lymph nodes

 Basic diseases:

• mononucleosis;
• lymphadenopathy in AIDS;
• progressive transformation of germinal centers (PTGC);
• castleman disease;
• toxoplasmosis;
• viral infections;
• silicon lymphadenopathy;
• lymphadenopathy in Wipple’s disease;
• cat scratch disease;
• lymphadenopathy in lupus erythematosus;
• dermatopathic lymphadenopathy;
• granulomatous lymphadenitis.

 Lymphoid tissue neoplastic diseases:

• WHO classification;
• lymphoid cell phenotype-definition; 
• antibodies used in diagnosis of lymphomas;
• phenotype of B-cell, T-cell and plasma cell;
• types and phenotype of dendritic and histiocytic cells;
• nodal and extranodal lymphomas.

Basic lymphomas, clinical course, epidemiology, phenotype:

• Hodgkin lymphoma;
• lymphoblastic leukemia/lymphoma;
• non-Hodgkin lymphomas;
• small cell B-cell lymphomas: lymphocytic lymphoma/chronic lymphocytic leukemia;
• mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma;
• large B-cell lymphoma, Burkitt lymphoma, plasma cell proliferative diseases;
• T-cell lymphomas:  anaplastic Alk+ i Alk-, skin lymphomas, peripheral T-cell lymphomas;
• dendritic and histiocytic proliferative diseases.

Neoplastic and non-neoplastic diseases of thymus and spleen.